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Antigenic Specificity | Human SMAC/Diablo |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | IgG |
Format | unconjugated |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (Diablo) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs. The current knowlege about structure and function of Smac/Diablo during programmed cell death, both in mitochondrial and receptor pathways are presented. It has been shown that Diablo mainly interacts with IAPs in the cytochrome c/Apaf-1/caspase-9 pathway, and promotes apoptosis. Diablo is released from the mitochondria into the cytosol occurring |
Immunogen | Immunogen: Recombinant Human SMAC/Diablo protein Buffer: 0.2 mum filtered solution in PBS with 5% trehalose |
Other Names | n/a |
Gene, Accession # | [SMAC/Diablo ] |
Catalog # | MBS2543946 |
Price | $215, $330, $500 |
Order / More Info | Human SMAC/Diablo Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |