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Antigenic Specificity | CASP5 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 2 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total CASP5 protein. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme.Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expres |
Immunogen | Immunogen: Fusion protein of human CASP5 |
Other Names | [ICH-3; ICEREL-III; ICE(rel)III] |
Gene, Accession # | [CASP5], Gene ID: 838, NCBI: NP_001129581.1, UniProt: P51878 |
Catalog # | MBS9416330 |
Price | $255 |
Order / More Info | CASP5 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |