IRS-1, phosphorylated (Tyr612) (Insulin Receptor Substrate 1) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | IRS-1, phosphorylated (Tyr612) (Insulin Receptor Substrate 1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 0.1 mL |
| Concentration | 0.25 mg/mL |
| Applications | Flow Cytometry (FC), Western Blot (WB), Immunohistochemistry (IHC). Other applications not tested. |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes human IRS-1 when phosphorylated at Tyr612. Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS-1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS-1 degradation pathways are not well understood. IRS-1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilme;s tumors, and adrenal cortical carcinomas, thus making IRS-1 phosphorylation and subsequent degradation an attractive therapeutic option. To date there have been four subtypes identified: I |
| Immunogen | Immunogen: Synthetic phosphopeptide derived from a region of human IRS-1 that contains tyrosine 612. Species sequence homology: rat, chicken. Positive Control: CHO-T cells transiently transfected with human IRS-1 |
| Other Names | [-IRS-1, phosphorylated (Tyr612) (Insulin Receptor Substrate 1)], [IRS1; IRS1; HIRS-1] |
| Gene, Accession # | Gene ID: 3667, NCBI: NP_005535.1, UniProt: P35568 |
| Catalog # | MBS624304 |
| Price | $635 |
| Order / More Info | IRS-1, phosphorylated (Tyr612) (Insulin Receptor Substrate 1) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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