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Antigenic Specificity | SQSTM1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human; mouse; rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Detects ~60 kDa. Band at 40 kDa is isoform 2. SQSTM1 or Sequestome 1 (p62) is a ubiquitin binding protein that interacts with ubiqutin, providing a scaffold for several signaling proteins and triggering degradation of proteins throught the proteasome or lysossome. This gene regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Mutations in this gene result in sporadic and familial Paget disease of bone. SQSTM1 also binds autophagosomal membrane protein LC3/ATG8. |
Immunogen | Immunogen: Synthetic peptide from the N-terminal to mid of Human SQSTM1 (aa. 195-205). Immunogen Species: Human. Cellular Localization: Cytoplasm; Late Endosome; Lysosome; Cytoplasmic Vesicle; Autophagosome; Nucleus; Endoplasmic Reticulum; Cytoplasm; P-Body. Conjugate: Unconjugated. Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide. Tissue Specificity: Ubiquitously expressed. |
Other Names | [Rabbit Human SQSTM1; EBI3-associated protein of 60 kDa; ORCA; Osi; SQSTM 1; ZIP 3; A170; SQSTM1; Ubiquitin binding protein p62; Protein kinase C-zeta-interacting protein; FTDALS3; Ubiquitin-binding protein p62; PKC-zeta-interacting protein; EBIAP; Sqstm1; Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa; EBI3 associated protein p60; EBI3 associated protein of 60 kDa; SQSTM_HUMAN; OSF-6; Paget disease of bone 3; p62B; p60; PDB 3; EBI 3 associated protein p60; MGC127197; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; EBI 3 associated protein of 60 kDa; ZIP3; STAP; p62; Sequestosome 1; OSIL; STONE14; Phosphotyrosine independent ligand for the Lck SH2 domain p62; PDB3; Oxidative stress induced like; Sequestosome-1; ZIP], [SQSTM1; SQSTM1; p60; p62; A170; DMRV; OSIL; PDB3; ZIP3; p62B; NADGP; FTDALS3; ORCA; OSIL; EBIAP; p60] |
Gene, Accession # | [SQSTM1], Gene ID: 8878, NCBI: NP_001135770.1, UniProt: Q13501 |
Catalog # | MBS809634 |
Price | $390 |
Order / More Info | SQSTM1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Kirkin V., et al. (2009) Mol Cell. 34: 259-269. 2. Seibenhener M.L., et al. (2007) FEBS Lett. 581: 175-179. 3. Komatsu M., et al. (2010) Nat Cell Biol. 12: 213-223. 4. Bjorkoy G., et al. (2006) Autophagy. 2: 138-139. 5. Pankiv S., et al. (2007) J Biol Chem. 282: 24131-24145. |