TERF2 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | TERF2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mg |
| Concentration | 1 mg/mL |
| Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: TERF2 antibody is human specific. The telomeric repeat binding factor family (TERF1 and TERF2) plays a key role in cellular immortalization and cellular senescence (1). TERF2, as a component of the telomere nucleoprotein complex, is present at telomeres in metaphase of the cell cycle (2). TERF2 is a second negative regulator of telomere length and binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway (2,3). TERF1 negatively regulates telomere elongation, while TERF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression (4,5). |
| Immunogen | Immunogen: TERF2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TERF2. Buffer: TERF2 Antibody is supplied in PBS containing 0.02% sodium azide. |
| Other Names | [TERF2; TRF2; TRBF2; TRF2; Telomeric repeat-binding factor 2; TTAGGG repeat-binding factor 2; telomeric repeat binding factor 2], [TERF2; TERF2; TRF2; TRBF2; TRBF2; TRF2] |
| Gene, Accession # | [TERF2], Gene ID: 7014, NCBI: NP_005643, UniProt: Q15554 |
| Catalog # | MBS153482 |
| Price | $375 |
| Order / More Info | TERF2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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