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Antigenic Specificity | V5 Tag |
Clone | [E10] |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | IgG1 |
Format | Protein A purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Dot Blot (DB), ELISA (EIA), Immunoprecipitation (IP), Immunostaining (IS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The anti-V5 Tag Antibody blocks host interferon signaling and induces the ubiquitination and subsequent proteasome-mediated degradation of host STAT1. It acts as an adapter, linking host DDB1-Cullin 4 to STAT2/STAT1 complex. There is an absolute requirement of STAT2 in STAT1 degradation, as V binds specifically to STAT2. It may also act as a chaperone keeping the viral nucleoprotein soluble. It interacts with host IFIH1/MDA5 to block its activity in the transduction pathway which leads to the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. |
Immunogen | Immunogen: GKPIPNPLLGLDST (V5) synthetic peptide conjugated to KLH |
Other Names | n/a |
Gene, Accession # | [V5 Tag] |
Catalog # | MBS395191 |
Price | $315 |
Order / More Info | V5 Tag Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |