EIF2A Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | EIF2A |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Phosphorylation of the eukaryotic initiation factor 2 (eIF2) alpha subunit is a well-documented mechanism to downregulate protein synthesis under a variety of stress conditions. eIF2 binds GTP and Met-tRNAi and transfers Met-tRNA to the 40S subunit to form the 43S preinitiation complex (1, 2). eIF2 promotes a new round of translation initiation by exchanging GDP for GTP, a reaction catalyzed by eIF2B (1, 2). Kinases that are activated by viral infection (PKR), endoplasmic reticulum stress (PERK/PEK), amino acid deprivation (GCN2), or heme deficiency (HRI) can phosphorylate the alpha subunit of eIF2 (3, 4). This phosphorylation stabilizes the eIF2-GDP-eIF2B complex and inhibits the turnover of eIF2B. Induction of PKR by IFN-gamma and TNF-alp |
| Immunogen | Immunogen: Fusion protein of human EIF2A Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [EIF2S1; EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A] |
| Gene, Accession # | [EIF2A], Gene ID: 1965, NCBI: NP_004085.1, UniProt: P05198 |
| Catalog # | MBS8527349 |
| Price | $310 |
| Order / More Info | EIF2A Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Kimball, S.R. (1999) Int. J. Biochem. Cell Biol. 31, 25-29. 2. De Haro, C. et al. (1996) FASEB J. 10, 1378-1387. 3. Kaufman, R.J. (1999) Genes Dev. 13, 1211-1233. 4. Sheikh, M.S. and Fornace Jr., A.J. (1999) Oncogene 18, 6121-6128. 5. Cheshire, J.L. et al. (1999) J. Biol. Chem. 274, 4801-4806. 6. Zamanian-Daryoush, M. et al. (2000) Mol. Cell. Biol. 20, 1278-1290. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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