c-Myc (C10) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | c-Myc (C10) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.2 mg |
| Concentration | 0.200 mg/ml |
| Applications | Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Human c-Myc p67, recognizes the 9E10 Myc tag. The transcription factor c-Myc is a proto-oncogene that is at the focal point in cell cycle regulation, metabolism, apoptosis, differentiation, cell adhesion, and tumorigenesis (1-3). In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated (2&3).c-Myc also plays a pivotal role in apoptosis, most notably its connections to the CD95/Fas death receptor pathway (1&4). These different biological responses to c-Myc are most likely the result of different overlapping subsets of c-Myc target genes (1). |
| Immunogen | Immunogen: synthetic peptide mapping near the carboxy terminal domain of human c-Myc. |
| Other Names | [c-myc, partial; C-myc protein; myc proto-oncogene protein; avian myelocytomatosis viral oncogene homolog; class E basic helix-loop-helix protein 39; myc-related translation/localization regulatory factor; proto-oncogene c-Myc; transcription factor p64; v-myc myelocytomatosis viral oncogene homolog; v-myc avian myelocytomatosis viral oncogene homolog; C-myc protein], [MYC; c-myc; MRTL; MYCC; c-Myc; bHLHe39] |
| Gene, Accession # | [cMyc], Gene ID: 4609, NCBI: CAA46984.1, UniProt: Q6LBK7 |
| Catalog # | MBS440055 |
| Price | $240 |
| Order / More Info | c-Myc (C10) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1.) Yakisich JS, Sandoval PY, Morrison TL, Kapler GM. 2006. TIF1 activates the intra-S-phase checkpoint response in the diploid micronucleus and amitotic polyploid macronucleus of Tetrahymena. Mol Biol Cell. Dec;17(12):5185-97.2.) Schmauch C, Maniak M. 2008. Competition between targeting signals in hybrid proteins provides information on their relative in vivo affinities for subcellular compartments. Eur J Cell Biol. Feb;87(2):57-68.1. Hoffman B, Amanullah A, Shafarenko M, Liebermann DA. 2002. The proto-oncogene c-myc in hematopoietic development and leukemogenesis. Oncogene 21(21): 3414-3421.2. Boxer LM, Dang CV. 2001. Translocations involving c-myc and c-myc function. Oncogene 20(40):5595-5610.3. Dang CV, Resar LM, Emison E, Kim S, Li Q, Prescott JE, Wonsey D, Zeller K. 1999. Function of the c-Myc oncogenic transcription factor. Exp Cell Res 253(1): 63-77.4. Prendergast GC. 1999. Mechanisms of apoptosis by c-Myc. Oncogene 18(19):2967-2987. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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