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Antigenic Specificity | AR Phospho-specific |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, mouse, dog |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | Size: 100 ug/200 ul |
Applications | ELISA, Western Blot, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes ~110 kDa of human AR protein. It also reacts with mouse and rat. The other species are not tested. The androgen receptor (AR), a member of nuclear receptor family, is essential for the growth of prostate cancer cells. The phosphorylation of AR is induced by growth factors and elevated in hormone-refractory prostate tumors. It's been reported the signal pathway of the PI3K/AKT, Src to be responsible for phosphorylation of AR at Ser213/210 and Ser81. The abnormal activation of AR is observed in many diseases, such as prostate cancer. |
Immunogen | Antigen Preparation: A synthetic peptide surrounding the epitope -EASGA- with a single phosphorylation site Ser210. This sequence is identical among human, rat, mouse, dog. |
Other Names | [Rabbit AR (pSer210); Androgen Receptor; Dihydrotestosterone Receptor], [AR; AR; KD; AIS; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA; DHTR; NR3C4] |
Gene, Accession # | Gene ID: 367, UniProt: P10275 |
Catalog # | MBS462012 |
Price | $285 |
Order / More Info | AR Phospho-specific Antibody from MYBIOSOURCE INC. |
Product Specific References | Yasumasa Ikeda, et al (2005), Androgen Receptor Gene Knockout Male Mice Exhibit Impaired Cardiac Growth and Exacerbation of Angiotensin II-induced Cardiac Fibrosis. J. Biol. Chem., Vol. 280, Issue 33, 29661-29666. |