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Antigenic Specificity | SP100 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: SP100 antibody detects endogenous levels of total SP100. Function: Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulat |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Nucleus > PML Body. Found in the nuclear body, also known as nuclear domain 10 (ND10), PML oncogenic domain (POD), nuclear dots (ND) and KR body. The nuclear body is a nucleoplasmic structure of punctate shape, which varies in size and number. Induction by interferon and may be cell cycle stages modulate the subnuclear localization of the isoforms. Tissue Specificity: Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mat |
Other Names | [DKFZp686E07254; FLJ00340; FLJ34579; Lysp100b; Nuclear antigen Sp100; Nuclear autoantigen Sp 100; Nuclear autoantigen Sp-100; Nuclear autoantigen Sp100; Nuclear dot associated Sp100 protein; Nuclear dot-associated Sp100 protein; SP 100; SP100; SP100 HMG nuclear autoantigen; SP100 nuclear antigen; SP100_HUMAN; Speckled 100 kDa] |
Gene, Accession # | [SP100], Gene ID: 6672, NCBI: NP_001073860.1, UniProt: P23497 |
Catalog # | MBS9605701 |
Price | $240, $280 |
Order / More Info | SP100 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |