CASP4 (p20, Cleaved-Gln81) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CASP4 (p20, Cleaved-Gln81) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: CASP4 (p20, Cleaved-Gln81) antibody detects endogenous levels of total CASP4 (p20, Cleaved-Gln81). Description: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.Function: Inflammatory caspase (PubMed:7797510, PubMed:23516580, PubMed:25119034). Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS (PubMed:22246630, PubMed:26174085, PubMed:26173988, PubMed:26508369, PubMed:25964352). Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release i |
| Immunogen | Immunogen: A synthesized peptide derived from human CASP4 (p20, Cleaved-Gln81) Subcellular Location: Endoplasmic Reticulum; Cytosol; Mitochondrion; Extracellular Region or Secreted Tissue Specificity: Widely expressed, including in keratinocytes and colonic and small intestinal epithelial cells (at protein level). Not detected in brain. |
| Other Names | [Apoptotic cysteine protease Mih1/TX; CASP-4; CASP4; CASP4_HUMAN; Caspase 4 apoptosis related cysteine peptidase; Caspase-4 subunit 2; Caspase4; ICE(rel)-II; ICE(rel)II; ICEREL II; ICH2; Mih1/TX; Protease ICH-2; Protease TX; TX] |
| Gene, Accession # | [CASP4], Gene ID: 837, NCBI: NP_001216.1, UniProt: P49662 |
| Catalog # | MBS9601545 |
| Price | $240, $280 |
| Order / More Info | CASP4 (p20, Cleaved-Gln81) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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