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Antigenic Specificity | CTLA4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 0.8 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total CTLA4 protein. This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthetic peptide corresponding to residues near the C terminal of human Cytotoxic T-lymphocyte protein 4 |
Other Names | [CD; GSE; GRD4; ICOS; CD152; CTLA-4; IDDM12; CELIAC3] |
Gene, Accession # | [CTLA4], Gene ID: 1493, NCBI: NP_001032720.1, UniProt: P16410 |
Catalog # | MBS9403611 |
Price | $255 |
Order / More Info | CTLA4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |