Copper Transporting ATPase 1 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Copper Transporting ATPase 1 |
| Clone | [S60-4] |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG2b |
| Format | ATTO 680 conjugate |
| Size | 0.1 mg |
| Concentration | 1mg/mL |
| Applications | Immunohistochemistry (IHC), Western Blot (WB), Immunoprecipitation (IP) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Background Info: Detects ~180kDa in rat brain membrane preparations. Scientific Background: The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-trans locating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased |
| Immunogen | n/a |
| Other Names | [ATP7A; ATP 7A; ATPase Cu transporting; DSMAX; FLJ17790; MC1; MC 1; MK; MNK; OHS; Copper pump 1; Menke; OTTHUMP00000062077; SMAX3; ATPase copper transporting alpha polypeptide; ATPase Cu++ transporting alpha polypeptide (Menkes syndrome)], [ATP7A; ATP7A; MK; MNK; DSMAX; SMAX3; MC1; MNK] |
| Gene, Accession # | Gene ID: 538, NCBI: NP_000043.3, UniProt: Q04656 |
| Catalog # | MBS800503 |
| Price | $440 |
| Order / More Info | Copper Transporting ATPase 1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Samimi G., et al. (2003) Clin. Cancer Res. 9: 5853-9. 2. Samimi G., et al. (2004) Mol Pharmacol. 66: 25-32. 3. Greenough M., et al. (2004) Am. J. Physiol. Cell Physiol. 287: C1463-71. 4. Song, I.S., et al. (2004) Mol. Cancer Ther. 3: 1543-1549. 5. van Dongen, E.M., et al. (2004) Biochem. Biophys. Res. Commun. 323: 789-795. 6. Samimi, G., et al. (2004) Mol Pharmacol 66: 25-32. 7. Morgan, C.T., et al. (2004) J. Biol. Chem. 279: 36363-36371. 8. Barnes, N., et al. (2005) J. Biol. Chem. [Epub]. |
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MYBIOSOURCE INC.
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