PKC-alpha (Ser-657/Tyr-658), phospho-specific Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | PKC-alpha (Ser-657/Tyr-658), phospho-specific |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat, rabbit |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA, Western Blot, Immunoprecipitation |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody detects an 82kDa* protein corresponding to the molecular mass of phosphorylated PKCa on SDSPAGE immunoblots of neonatal rat brain lysate. Similar results were observed in human SKN-SH, endothelial, and HeLa cells, as well as rabbit spleen fibroblasts and rat pituitary cells. In immunoprecipitation experiments with various PKC isoforms, this antibody detected PKCa and PKCb but not other PKC isoforms in rat brain lysate. The Protein Kinase C (PKC) family of homologous serine/threonine protein kinases is involved in a number of processes such as growth, differentiation, and cytokine secretion. At least eleven isozymes have been described. PKC consists of a single polypeptide chain containing four conserved regions (C) and five va |
| Immunogen | Immunogen: Phospho-PKCa (Ser-657/Tyr-658) synthetic peptide corresponds to amino acid residues around serine 657 and tyrosine 658 of human PKCa. This sequence is similar to the conserved sites in rat and mouse, and has high homology to dual sites in human, rat, and mouse PKCbI (Ser-661/Tyr-662) and PKCg (Thr-674/Tyr675). |
| Other Names | [PKC a (Ser-657/Tyr-658); phospho-specific; Protein Kinase C alpha], [PRKCA; PRKCA; AAG6; PKCA; PRKACA; MGC129900; MGC129901; PKC-alpha; PKCA; PRKACA] |
| Gene, Accession # | Gene ID: 5578, NCBI: P17252.3, UniProt: P17252 |
| Catalog # | MBS472052 |
| Price | $385 |
| Order / More Info | PKC-alpha (Ser-657/Tyr-658), phospho-specific Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Kawakami et al. (2003) Proc. Natl. Acad. Sci. USA 100:9470-9475.• Nishizuka, Y. (1988) Nature 334:661. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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