Mouse CD11b/Mac-1a Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Mouse CD11b/Mac-1a |
| Clone | [3A33] |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2a kappa |
| Format | unconjugated |
| Size | 0.5 mg |
| Concentration | n/a |
| Applications | Flow Cytometry; Immunohistochemistry (Frozen Sections); Immunoprecipitation |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: alpha M subunit (Mr 170 kDa) of the CD11b/CD18 heterodimer>br>CD11b (integrin alpha M subunit) combines with CD18 (integrin beta 2 subunit) to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1 (CD54).^2-6 Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities.^2, 7-10 In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process,^4, 11 Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils.^12. |
| Immunogen | Immunogen: Peritoneal macrophages from C57 B1/6 x DBA/2 F1 hybrid mice |
| Other Names | [Rat Mouse CD11b/Mac-1a - Purified, Unlabeled; Rat Mouse CD11b/Mac-1], [ITGAM; CR3; C3bi; CD11B] |
| Gene, Accession # | Gene ID: 443217 |
| Catalog # | MBS673206 |
| Price | $235 |
| Order / More Info | Mouse CD11b/Mac-1a Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Martin, A., R. Le Corre, P. Pellen,, D. Bourel, G. Merdrignac, B. Genetet, and L. Toujas. 1986. Tissue Antigens 28:15.2. Springer, T., G. Galfre, D.S. Secher, and C. Milstein. 1979. Eur. J. Immunol. 9:301.3. Springer, T.A., D. Davignon, M.-K. Ho, K. Kurzinger, E. Martz, and F. Sanchez-Madrid. 1982. Immunol. Rev. 68:171.4. Beller, D.I., T.A. Springer, R.D. Schreiber. 1982. J. Exp. Med. 156:1000.5. Sanchez-Madrid, F., P. Simon, S. Thompson, and T.A. Springer. 1983. J. Exp. Med. 158:586.6. Lub, M., Y. van Kooyk, and C.J. Figdor. 1996. J. Leukoc. Biol. 59:648.7. Kantor, A.B., A. M. Stall, S. Adams, L.A. Herzenberg, and L.A. Herzenberg. 1992. Proc. Natl. Acad. Sci. USA 89:3320.8. Ault, K.A., and T.A. Springer. 1981. J. Immunol. 126:359.9. Vremec, D., M. Zorbas, R. Scollay, D.J. Saunders, C.F. Ardavin, L. Wu, and K. Shrotman. 1992. J. Exp. Med. 176:47.10. Leenen, P.J. M., M.F.T.R. de Bruijn, J.S.A. Voerman, P.A. Campbell, and W. van Ewijk. 1994. J. Immunol. Meth. 174:5.11. Gresham, H.D., et al. 1991. J. Clin. Invest. 88:588.12. Springer, T.A. 1994. Cell 76:310. |
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