Edit |   |
---|---|
Antigenic Specificity | PPARGC1A |
Clone | [AT25C8] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a, k |
Format | Protein A purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1 mg/ml |
Applications | ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | PPARGC1A is transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. This protein can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis and plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Also, induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner and involved in the integration of the circadian rhythms and energy metabolism. They required for oscillatory expression of clock genes, such as |
Immunogen | Immunogen: Recombinant human PPARGC1A (300-540aa) purified from E. coli |
Other Names | [peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 2; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PPARG coactivator 1 alpha; Ligand effect modulator 6], [PPARGC1A; PPARGC1A; LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1alpha; PGC-1(alpha); LEM6; PGC1; PGC1A; PPARGC1; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha] |
Gene, Accession # | [PPARGC1A], Gene ID: 10891, NCBI: NP_037393, UniProt: Q9UBK2 |
Catalog # | MBS206582 |
Price | $240, $315 |
Order / More Info | PPARGC1A Antibody from MYBIOSOURCE INC. |
Product Specific References | Lui Z., et al. (2016) Sci Rep. 6: 21382.; Li R., et al. (2016) Med Sci Monit. 22: 3229-3237. |