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Antigenic Specificity | RIG-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG-1) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG-1 activates the kinases TBK1 and IKKeta through the adaptor protein IPS-1. These kinases then phosphorylate the transcription factors IRF-3 and IRF-7 which are essential for the expression of type-I interferons. RIG-1 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus. |
Immunogen | Immunogen Type: Recombinant protein Immunogen Description: Raised against human GST-tagged RIG-1 protein. |
Other Names | [Retinoic acid inducible gene 1 protein, RIG-I, Dead box protein 58, ddx58] |
Gene, Accession # | [RIG-1], Gene ID: 23586, NCBI: NP_055129.2, UniProt: O95786 |
Catalog # | MBS9402395 |
Price | $320 |
Order / More Info | RIG-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |