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Antigenic Specificity | RWDD3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | RWDD3 Antibody: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases IκBeta sumoylation and stability. In addition, RWDD3 inhibits TNF-α-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of IκBeta increased stability. RSUME-enhanced sumoylation of IκBeta leads to the inhibition of NF-κBeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD |
Immunogen | Immunogen: RWDD3 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human RWDD3. Buffer: RWDD3 Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [RWDD3; RSUME; RSUME; RWD domain-containing protein 3; RWD-containing sumoylation enhancer; RWD domain containing 3], [RWDD3; RWDD3; RSUME; RSUME; RSUME] |
Gene, Accession # | [RWDD3], Gene ID: 25950, NCBI: NP_056300, UniProt: Q9Y3V2 |
Catalog # | MBS150223 |
Price | $375 |
Order / More Info | RWDD3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |