Human CD275(B7-H2) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human CD275(B7-H2) |
| Clone | [ANC4E3] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1k |
| Format | no preservative |
| Size | 0.1 mg |
| Concentration | 1.0 mg/ml |
| Applications | ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Information: The inducible costimulator (ICOS, T cell activation molecule H4) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process. Unlike CD28, ICOS is only expressed on activated T cells. Secondary signaling through CD28 or ICOS results in discrete cytokine secretion profiles by the activated T cells(1). Engagement of CD152 (CTLA-4) anergizes cells costimulated with either CD28 and ICOS(2). Signaling through ICOS is particularly important in progression of TH2 immune response (5). The receptor for human ICOS is GL50(ICOS L), a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2)(3). Two RNA splice variants exist for this molecule, differing only in the cytoplasmic |
| Immunogen | Immunogen: Human Raji cells, recombinant human CD275-muIg |
| Other Names | n/a |
| Gene, Accession # | [CD275] |
| Catalog # | MBS666170 |
| Price | $310 |
| Order / More Info | Human CD275(B7-H2) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1) Beier, K.C., R.A. Kroczek, et al. 2000, Eur J Immunol. 30(12):3707-3717. 2) Riley, J.L., C.H. June, et al. 2001, J. Immunol. 166: 4943-4948. 3) Ling, V., M. Collins, et al. 2000, J. Immunol. 164: 1653-1657. 4) Ling, V., M. Collins, et al. 2001, J. Immunol. 166: 7300-7308. 5) K.C. Beier, et al, (2000) Eur J Immunol 30: 3707-3717. 6) E. Ozkaynak, et al, (2001) Nat Immunol 2: 591-596. 7) J.B. Rottman, et al, (2001) Nat Immunol 2: 605-611. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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