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Antigenic Specificity | EEA1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: EEA1 Antibody detects endogenous levels of total EEA1. EEA1 is an early endosomal marker and a Rab5 effector protein essential for early endosomal membrane fusion and trafficking (1-2). The carboxy terminus of EEA1 contains a FYVE domain which binds to phosphatidylinositol-3-phosphate (PtdIns(3)P), targeting EEA1 to early endosomes (3). The stable association of EEA1 with the endosomal membrane is regulated by PI3 kinase, Rab5 and calcium/calmodulin (4-6). Once on the membrane, EEA1 interacts with Rab5, NSF and syntaxin 13 to promote early endosomal membrane docking and fusion (7). |
Immunogen | Immunogen: A synthesized peptide derived from human EEA1 |
Other Names | [Early endosome antigen 1; EEA1; MST105; ZFYVE2] |
Gene, Accession # | [EEA1], Gene ID: 8411, NCBI: NP_003557.2, UniProt: Q15075 |
Catalog # | MBS4750054 |
Price | $335 |
Order / More Info | EEA1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |