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Antigenic Specificity | Lactate Dehydrogenase A/LDHA, Human |
Clone | AT1A4 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b kappa |
Format | Protein G purified |
Size | 50ul, 100ul |
Concentration | 1mg/ml (determined by BCA assay) |
Applications | ELISA, WB, ICC/IF |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc and hypoxia-inducible factor (HIF-1). LDHA expression is repressed by SugR in the absence of sugar. Reduction of LDHA causes bioenergetic and oxidative stress leading to cell death. LDHA (LDH-5, M-LDH, or A4), which is the predominant form in skeletal muscle, kinetically favors the conversion of pyruvate to lactate. Therefore, LDH-A is an attractive target for cancer therapy since its expression is largely relegated to skeletal muscle. |
Immunogen | Recombinant human LDHA (1-332aa) purified from E.coli |
Other Names | Lactate dehydrogenase A, L-lactate dehydrogenase A chain, Cell proliferation-inducing gene 19 protein, PIG19, LDH muscle subunit, LDH-M, Renal carcinoma antigen NY-REN-59 |
Gene, Accession # | NCBI: NP_005557, UniProt: P00338 |
Catalog # | ATGA0180 |
Price | $170, $290 |
Order / More Info | Lactate Dehydrogenase A/LDHA, Human Antibody from NKMAX Co. Ltd. |
Product Specific References | n/a |