SETD7, Human Antibody from NKMAX Co. Ltd.
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| Antigenic Specificity | SETD7, Human |
| Clone | s4E5 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b kappa |
| Format | Protein A purified |
| Size | 50ul, 100ul |
| Concentration | 1mg/ml (determined by BCA assay) |
| Applications | ELISA, WB, ICC/IF, FACS |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | SET 7/9 is a histone methyltransferase (HMTase) that transfers methyl group to Lys4 of histone H3, in complex with S-adenosyl-L-methionine (AdoMet). The methylation of lysine residues of histones plays a critical role in the regulation of chromatin structure and gene expression. Acetylation, phosphorylation and methylation of the amino-terminal tails of histone are thought to be involved in the regulation of chromatin structure and function. The enzymes identified in the methylation of specific lysine residue on histones belong to the SET family with just one exception. Set7/9, unlike most other SET proteins, is exclusively a mono-methylase. |
| Immunogen | Recombinant human SET 7/9 (1-366aa) purified from E. coli |
| Other Names | SETD7, SET7, SET9, SET7/9, SET7/9 Histone methyltransferase, SET domain-containing protein 8, SET domain-containing protein 7 FLJ21193, SET domain-containing protein 7, Lysine N-methyltransferase 7, Lysine methyltransferase, KMT7, KIAA1717, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase, Histone lysine N methyltransferase H3 lysine 4 specific SET7, Histone lysine methyltransferase, Histone H4-K4 methyltransferase, Histone H3-K4 methyltransferase SETD7, Histone H3 lysine 4 specific methyltransferase, Histone H3 K4 methyltransferase, H4 lysine-4 specific, H3-K4-HMTase SETD7, H3 K4 HMTase, EC 2.1.1.43 |
| Gene, Accession # | NCBI: NP_085151, UniProt: Q8WTS6 |
| Catalog # | AHR0401 |
| Price | $170, $290 |
| Order / More Info | SETD7, Human Antibody from NKMAX Co. Ltd. |
| Product Specific References | Kurash JK, et al. Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. (Mol Cell. 2008){https://pubmed.ncbi.nlm.nih.gov/18280244/};;Tao Y, et al. The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. (J Cell Biol. 2011){https://pubmed.ncbi.nlm.nih.gov/21859860/};;Han T, et al. Set7 facilitates hepatitis C virus replication via enzymatic activity-dependent attenuation of the IFN-related pathway. (J Immunol. 2015){https://pubmed.ncbi.nlm.nih.gov/25681344/};;Zhang Y, et al. The transcription factor GATA1 and the histone methyltransferase SET7 interact to promote VEGF-mediated angiogenesis and tumor growth and predict clinical outcome of breast cancer. (Oncotarget. 2016){https://pubmed.ncbi.nlm.nih.gov/26848522/};;Yuan H, et al. Epigenetic Histone Modifications Involved in Profibrotic Gene Regulation by 12/15-Lipoxygenase and Its Oxidized Lipid Products in Diabetic Nephropathy. (Antioxid Redox Signal. 2016){https://pubmed.ncbi.nlm.nih.gov/26492974/};;Xu X, et al. A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity. (Nat Commun. 2017){https://pubmed.ncbi.nlm.nih.gov/28094252/} |
NKMAX Co. Ltd.
NKMAX Co. Ltd.
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