MERS-CoV Spike Antibody from NKMAX Co. Ltd.
Search, find, compare suppliers for anti-MERS-CoV Spike antibody, protein, ELISA kits.
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| Antigenic Specificity | MERS-CoV Spike |
| Clone | AT25E4 |
| Host Species | Mouse |
| Reactive Species | MERS-CoV |
| Isotype | IgG1 kappa |
| Format | Protein A purified |
| Size | 50ul, 100ul |
| Concentration | 1mg/ml (determined by BCA assay) |
| Applications | ELISA |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MERS Spike Antibody (1ug/ml) specifically recognizes MERS Spike, Spike S1 and RBD recombinant protein, but not interacted MERS Spike S2 recombinant protein in ELISA.. 25E4 mAb showed broad neutralizing activity. (Virus Res. 2020 Mar 278:197863). MERS-CoV, which causes the Middles East Respiratory Syndrome (MERS), belongs to a family of viruses known as coronaviruses. MERS-CoV was first identified in the Kingdom of Saudi Arabia in 2012, which is a single and positive stranded RNA virus. Dromedary camels are widely considered as the source of the transmission of MERS-CoV. The rate of human transmission among household contacts of MERS patients has been approximately 5 % based on serological analysis. MERS-CoV has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The spike protein, responsible for allowing the virus to attach to and fuse with the membrane of a host cell and is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. MERS-CoV S mediates viral attachment and fusion to human cells via human cellular receptor DPP4, also known as CD26. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. |
| Immunogen | Recombinant MERS-CoV Spike (18-1296aa) purified from Baculovirus |
| Other Names | Middle East respiratory syndrome coronavirus, Human betacoronavirus 2c EMC/2012, MERS-CoV, MERS, MERS-CoV SP, Spike glycoprotein, S glycoprotein, S, Spike protein |
| Gene, Accession # | NCBI: AFS88936, UniProt: K0BRG7 |
| Catalog # | ATGA0597 |
| Price | $170, $290 |
| Order / More Info | MERS-CoV Spike Antibody from NKMAX Co. Ltd. |
| Product Specific References | Lee K, et al. Development of a diagnostic system for detection of specific antibodies and antigens against Middle East respiratory syndrome coronavirus. (Microbiol Immunol. 2018){https://pubmed.ncbi.nlm.nih.gov/30117617/};;Goo J, et al. Characterization of novel monoclonal antibodies against MERS-coronavirus spike protein. (Virus Res. 2020){https://pubmed.ncbi.nlm.nih.gov/31945421/} |
NKMAX Co. Ltd.
NKMAX Co. Ltd.
6F, SNUH Health Care Innovation Park
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do 13605 REPUBLIC OF KOREA
P: +82-31-8017-8114
F: +82-31-8017-8124
salesbio@nkmax.com
http://www.nkmaxbio.com
Profile of NKMAX Co. Ltd.