HTRA2/OMI (S306A), Human Antibody from NKMAX Co. Ltd.
Search, find, compare suppliers for anti-HTRA2/OMI (S306A), Human antibody, protein, ELISA kits.
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| Antigenic Specificity | HTRA2/OMI (S306A), Human |
| Clone | 1B3 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | Protein G purified |
| Size | 50ul, 100ul |
| Concentration | 1mg/ml (determined by BCA assay) |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | HtrA2/Omi is a mammalian serine protease at high temperatures and a chaperone at low temperature. The full-length HtrA2 is synthesized as a precursor protein and then targeted to the mitochondria where it is matured by the removal of N-terminal 133 residues. Mature HtrA2 consists of a putative transmembrane domain; an inhibitor of apoptosis protein (IAP) -binding motif; a single C-terminal PDZ domain that mediates protein-protein interactions. Recently, HtrA2 has known to contribute both to caspase-dependent and caspase-independent cell death. |
| Immunogen | Recombinant human HtrA2/Omi (134-458aa) purified from E. coli |
| Other Names | HtrA serine peptidase 2, High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, PRSS25, OMI, PARK13 |
| Gene, Accession # | NCBI: NP_037379, UniProt: O43464 |
| Catalog # | AOH0607 |
| Price | $170, $290 |
| Order / More Info | HTRA2/OMI (S306A), Human Antibody from NKMAX Co. Ltd. |
| Product Specific References | Kim GY, et al. A simple and rapid strategy for the molecular cloning and monitoring of mouse HtrA2 serine protease. (Biotechnol Lett. 2008){https://pubmed.ncbi.nlm.nih.gov/17939055/};;Park HJ, et al. Intracellular Abeta and C99 aggregates induce mitochondria-dependent cell death in human neuroglioma H4 cells through recruitment of the 20S proteasome subunits. (Brain Res. 2009){https://pubmed.ncbi.nlm.nih.gov/19362074/};;Shin EJ, et al. Matrix metalloproteinase-3 is activated by HtrA2/Omi in dopaminergic cells: relevance to Parkinsons disease. (Neurochem Int. 2012){https://pubmed.ncbi.nlm.nih.gov/22265821/};;Goo HG, et al. HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA. (Biochim Biophys Acta. 2013){https://pubmed.ncbi.nlm.nih.gov/23542127/};;Goo HG, et al. HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis. (Exp Cell Res. 2014){https://pubmed.ncbi.nlm.nih.gov/25094062/};;Nam MK, et al. HtrA2 regulates α-Synuclein-mediated mitochondrial reactive oxygen species production in the mitochondria of microglia. (Biochem Biophys Res Commun. 2023){https://pubmed.ncbi.nlm.nih.gov/36442236/} |
NKMAX Co. Ltd.
NKMAX Co. Ltd.
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