IRF5, Human Antibody from NKMAX Co. Ltd.
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| Antigenic Specificity | IRF5, Human |
| Clone | 10T1 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | Protein A purified |
| Size | 50ul, 100ul |
| Concentration | 1mg/ml (determined by BCA assay) |
| Applications | ELISA, WB, ICC/IF, IHC, FACS |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Interferon regulatory factor 5 (IRF-5) is a member of IRF family, which plays a critical role in the regulation of genes induced by viral infection, immunostimulation and cell growth regulation. The expression of IRF-5 is limited to lymphoid organs, dendritic cells, and peripheral blood lymphocytes, but is not expressed in numerous leukemia and lymphoma cell lines. Three IRFs (IRF-3, IRF-5, IRF-7) function as direct transducers of virus-mediated signaling and play a critical role in the expression of type I interferon genes and some chemokines. |
| Immunogen | Recombinant human IRF-5 (176-240aa) purified from E. coli |
| Other Names | interferon regulatory factor 5, irf5 |
| Gene, Accession # | NCBI: NP_116032.1, UniProt: Q13568 |
| Catalog # | AIR0611 |
| Price | $170, $290 |
| Order / More Info | IRF5, Human Antibody from NKMAX Co. Ltd. |
| Product Specific References | Barro M, Patton JT. Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7. (J Virol. 2007){https://pubmed.ncbi.nlm.nih.gov/17301153/};;Watanabe T, et al. Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. (J Clin Invest. 2008){https://www.ncbi.nlm.nih.gov/pubmed/18188453};;Ye L, et al. Methamphetamine enhances Hepatitis C virus replication in human hepatocytes. (J Viral Hepat. 2008){https://pubmed.ncbi.nlm.nih.gov/18307590/};;Pandey AK, et al. NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis. (PLoS Pathog. 2009){https://www.ncbi.nlm.nih.gov/pubmed/19578435};;Polioudakis D, et al. A Myc-microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes. (Nucleic Acids Res. 2013){https://pubmed.ncbi.nlm.nih.gov/23303785/};;Steinhagen F, et al. IRF-5 and NF-κB p50 co-regulate IFN-β and IL-6 expression in TLR9-stimulated human plasmacytoid dendritic cells. (Eur J Immunol. 2013){https://pubmed.ncbi.nlm.nih.gov/23616277/};;He H, et al. Immobilized heavy chain-hyaluronic acid polarizes lipopolysaccharide-activated macrophages toward M2 phenotype. (J Biol Chem. 2013){https://pubmed.ncbi.nlm.nih.gov/23878196/};;O Carroll C, et al. Identification of a unique hybrid macrophage-polarization state following recovery from lipopolysaccharide tolerance. (J Immunol. 2014){https://pubmed.ncbi.nlm.nih.gov/24337373/};;Chionh YT, et al. Protease-activated receptor 1 suppresses Helicobacter pylori gastritis via the inhibition of macrophage cytokine secretion and interferon regulatory factor 5. (Mucosal Immunol. 2015){https://pubmed.ncbi.nlm.nih.gov/24866378/};;Steinhagen F, et al. IRF5 and IRF8 modulate the CAL-1 human plasmacytoid dendritic cell line response following TLR9 ligation. (Eur J Immunol. 2016){https://pubmed.ncbi.nlm.nih.gov/26613957/};;Li D, et al. Specific detection of interferon regulatory factor 5 (IRF5): A case of antibody inequality. (Sci Rep. 2016){https://pubmed.ncbi.nlm.nih.gov/27481535/};;Koelzer VH, et al. Digital analysis and epigenetic regulation of the signature of rejection in colorectal cancer. (Oncoimmunology. 2017){https://pubmed.ncbi.nlm.nih.gov/28507795/};;Xiao Y, et al. An oligodeoxynucleotide with AAAG repeats significantly attenuates burn-induced systemic inflammatory responses via inhibiting interferon regulatory factor 5 pathway. (Mol Med. 2017){https://pubmed.ncbi.nlm.nih.gov/28620671/};;Chen X, et al. MicroRNA-302a suppresses influenza A virus-stimulated interferon regulatory factor-5 expression and cytokine storm induction. (J Biol Chem. 2017){https://pubmed.ncbi.nlm.nih.gov/29046356/} |
NKMAX Co. Ltd.
NKMAX Co. Ltd.
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