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Antigenic Specificity | TDP-43/TARDBP, Human |
Clone | k1B8 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 kappa |
Format | Protein G purified |
Size | 50ul, 100ul |
Concentration | 1mg/ml (determined by BCA assay) |
Applications | ELISA, WB, IHC, FACS |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene. |
Immunogen | Recombinant human TARDBP (1-260aa) purified from E. coli |
Other Names | TAR DNA binding protein, TDP-43, ALS10, TAR DNA-binding protein 43, TDP43 |
Gene, Accession # | NCBI: NP_031401, UniProt: Q13148 |
Catalog # | ATA0834 |
Price | $170, $290 |
Order / More Info | TDP-43/TARDBP, Human Antibody from NKMAX Co. Ltd. |
Product Specific References | n/a |