NKp46/NCR1, Human Antibody from NKMAX Co. Ltd.
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| Antigenic Specificity | NKp46/NCR1, Human |
| Clone | n1D9 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | Protein G purified |
| Size | 50ul, 100ul |
| Concentration | 1mg/ml (determined by BCA assay) |
| Applications | ELISA, WB, FACS |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | A natural cytotoxicity receptor (NCR), Nkp46, is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 residue stalk resion, a type I transmembrane domain, and a short cytoplasmic tail. Nkp46 has been shown to represent a novel Nk cell-specific molecule involved in human Nk cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. Nkp46 has been implicated in Nk cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. |
| Immunogen | Recombinant human Nkp46 (22-255aa) purified from E. coli |
| Other Names | NKp46 Extracellular Ig-like domain, NK-p46, NK cell-activating receptor, NCR1, NCR, Natural killer cell p46-related protein, Natural cytotoxicity triggering receptor 1 isoform a, Natural cytotoxicity triggering receptor 1, Lymphocyte antigen 94 homolog, Ly96, LY94, hNKp46, CD335 antigen |
| Gene, Accession # | NCBI: NP_004820, UniProt: O76036 |
| Catalog # | AKR0408 |
| Price | $170, $290 |
| Order / More Info | NKp46/NCR1, Human Antibody from NKMAX Co. Ltd. |
| Product Specific References | Ascierto ML, et al. Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients. (J Transl Med. 2013){https://pubmed.ncbi.nlm.nih.gov/23758773/};;Haberthur K, et al. NKG2D ligand expression in pediatric brain tumors. (Cancer Biol Ther. 2016){https://pubmed.ncbi.nlm.nih.gov/27834580/};;Qu S, et al. Aneustat (OMN54) has aerobic glycolysis-inhibitory activity and also immunomodulatory activity as indicated by a first-generation PDX prostate cancer model. (Int J Cancer. 2018){https://pubmed.ncbi.nlm.nih.gov/29441566/} |
NKMAX Co. Ltd.
NKMAX Co. Ltd.
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