MINCLE/CLEC4E, Human Antibody from NKMAX Co. Ltd.
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| Antigenic Specificity | MINCLE/CLEC4E, Human |
| Clone | AT16E3 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b kappa |
| Format | Protein G purified |
| Size | 50ul, 100ul |
| Concentration | 1mg/ml (determined by BCA assay) |
| Applications | ELISA, WB, ICC/IF, IHC, FACS |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CLEC4E (macrophage inducible C-type lectin, also called MINCLE or CLECSF9), which is a diverse family of protein which was originally defined by their ability to recognize a wide range of ligand of carbohydrate structure. CLEC4E expressed in macrophages subjected to several types of stress. It plays an essential role in response to trehalose-6, 6'-dimycolate (TDM) and activated by a synthetic analogue, trehalose dibehenate (TDB). Recently it was reported that CLEC4E is associated with an immunoreceptor tyrosine-based activation motif-containing Fc receptor gamma chain (FcRgamma) and functions as an activating receptor for damaged self- and non-self-pathogenic fungi. |
| Immunogen | Recombinant human MINCLE (41-219aa) purified from E.coli |
| Other Names | CLEC4E, CLECSF9, C-type lectin domain family 4 member E, C-type lectin superfamily member 9, Macrophage lectin 2, Macrophage-inducible C-type lectin, MINCLE, NtmntanCLEC4E Ege lectin 2 |
| Gene, Accession # | NCBI: NP_055173, UniProt: Q9ULY5 |
| Catalog # | ATGA0175 |
| Price | $170, $290 |
| Order / More Info | MINCLE/CLEC4E, Human Antibody from NKMAX Co. Ltd. |
| Product Specific References | Seifert L, et al. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. (Nature. 2016){https://pubmed.ncbi.nlm.nih.gov/27049944/};;Zhao X, et al. Activation of C-Type Lectin Receptor and (RIG)-I-Like Receptors Contributes to Proinflammatory Response in Middle East Respiratory Syndrome Coronavirus-Infected Macrophages. (J Infect Dis. 2020){https://pubmed.ncbi.nlm.nih.gov/31562757/} |
NKMAX Co. Ltd.
NKMAX Co. Ltd.
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Seongnam-si, Gyeonggi-do 13605 REPUBLIC OF KOREA
P: +82-31-8017-8114
F: +82-31-8017-8124
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http://www.nkmaxbio.com
Profile of NKMAX Co. Ltd.