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Antigenic Specificity | HMG-1/HMGB1, Human |
Clone | J2E1 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b kappa |
Format | Protein G purified |
Size | 50ul, 100ul |
Concentration | 1mg/ml (determined by BCA assay) |
Applications | ELISA, WB, IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | High mobility group box1 protein (HMGB1) is a very abundant chromatin-binding protein residing in the eukaryotic cell nucleus and acting in the assembly of nucleoprotein complexes. Inside the cell, HMGB1 binds to DNA and has a role in transcriptional regulation. Outside the cell, HMGB1 acts as a cytokine and has activities that resemble those of tumor necrosis factor. |
Immunogen | Recombinant human HMGB1 (1-215aa) purified from Baculovirus |
Other Names | Sulfoglucuronyl carbohydrate binding protein, SBP-1, HMGB1, HMG3, HMG1, High-mobility group box1, High-mobility group (nonhistone chromosomal) protein 1, DKFZp686A04236, Amphoterin |
Gene, Accession # | NCBI: NP_002119, UniProt: P09429 |
Catalog # | AHM0915 |
Price | $170, $290 |
Order / More Info | HMG-1/HMGB1, Human Antibody from NKMAX Co. Ltd. |
Product Specific References | Hashizume H, et al. Skin recruitment of monomyeloid precursors involves human herpesvirus-6 reactivation in drug allergy. (Allergy. 2013){https://pubmed.ncbi.nlm.nih.gov/23573902/};;Ito H, et al. HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice. 9EMBO Mol Med. 2015){https://pubmed.ncbi.nlm.nih.gov/25510912/} |