APP/Protease Nexin II, Human Antibody from NKMAX Co. Ltd.

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Antigenic SpecificityAPP/Protease Nexin II, Human
CloneJ4H9
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG2b kappa
FormatProtein G purified
Size50ul, 100ul
Concentration1mg/ml (determined by BCA assay)
ApplicationsELISA, WB, ICC/IF, FACS
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DescriptionAmyloid precursor protein (APP) is the precursor molecule whose proteolysis generates amyloid beta (AB), a 39- to 42- amino acid peptide and this amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's diseases patients. APP is an integral membrane protein that is phosphorylated in the cytoplasmic and extracellular domains. It has been reported that cell-surface APP plays a role in neurite extension of primary cultured hippocampal neurons. The large extracellular domain of APP is also reported to bind extracellular matrix molecules such as heparin, laminin, and collagen, which can mediate cell adhesion and neurite outgrowth. Abnormal regulation of the metabolism of APP may contribute to the deposition of plaques.
ImmunogenRecombinant human APP (18-289aa) purified from E. coli
Other Namesamyloid beta A4 protein precursor, isoform, amyloid beta (A4) precursor protein, Alzheimer disease, peptidase nexin-II
Gene, Accession #NCBI: NP_000475, UniProt: P05067
Catalog #AAP0836
Price$170, $290
Order / More InfoAPP/Protease Nexin II, Human Antibody from NKMAX Co. Ltd.
Product Specific Referencesn/a
NKMAX Co. Ltd.
NKMAX Co. Ltd.
NKMAX Co. Ltd.
6F, SNUH Health Care Innovation Park
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do 13605 REPUBLIC OF KOREA
P: +82-31-8017-8114
F: +82-31-8017-8124

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