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Antigenic Specificity | CD46, Human |
Clone | AT2G9 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a kappa |
Format | Protein A purified |
Size | 50ul, 100ul |
Concentration | 1mg/ml (determined by BCA assay) |
Applications | ELISA,WB,ICC/IF,IHC,FACS |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Membrane Cofactor Protein (CD46) is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 regulates the complement cascade by inhibiting C3b and C4b deposited on self tissue. This protein is a cofactor that binds to C3b and C4b, allowing their degradation by a plasma serine protease called factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is implicated in the development and/or progression of selected cancer types. |
Immunogen | Recombinant human CD46 (35-313aa) purified from E. coli |
Other Names | Membrane cofactor protein isoform 14, AHuS2, MCP, MIC10, TLX, TRA2.10 |
Gene, Accession # | NCBI: NP_758860, UniProt: P15529 |
Catalog # | ATGA0326 |
Price | $170, $290 |
Order / More Info | CD46, Human Antibody from NKMAX Co. Ltd. |
Product Specific References | n/a |