SETD7, Human Antibody from NKMAX Co. Ltd.
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| Antigenic Specificity | SETD7, Human |
| Clone | s4E5 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b kappa |
| Format | Protein A purified |
| Size | 50ul, 100ul |
| Concentration | 1mg/ml (determined by BCA assay) |
| Applications | ELISA, WB, ICC/IF, FACS |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Set7/9 is a histone methyltransferase (HMTase) that transfers methyl group to Lys4 of histone H3, in complex with S-adenosyl-L-methionine (AdoMet). The methylation of lysine residues of histones plays a critical role in the regulation of chromatin structure and gene expression. Acetylation, phosphorylation and methylation of the amino-terminal tails of histone are thought to be involved in the regulation of chromatin structure and function. The enzymes identified in the methylation of specific lysine residue on histones belong to the SET family with just one exception. Set7/9, unlike most other SET proteins, is exclusively a mono-methylase. |
| Immunogen | Recombinant human SET7/9 (1-366aa) purified from E. coli |
| Other Names | SETD7, SET7, SET9, SET7/9, SET7/9 Histone methyltransferase, SET domain-containing protein 8, SET domain-containing protein 7 FLJ21193, SET domain-containing protein 7, Lysine N-methyltransferase 7, Lysine methyltransferase, KMT7, KIAA1717, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase, Histone lysine N methyltransferase H3 lysine 4 specific SET7, Histone lysine methyltransferase, Histone H4-K4 methyltransferase, Histone H3-K4 methyltransferase SETD7, Histone H3 lysine 4 specific methyltransferase, Histone H3 K4 methyltransferase, H4 lysine-4 specific, H3-K4-HMTase SETD7, H3 K4 HMTase, EC 2.1.1.43 |
| Gene, Accession # | NCBI: NP_085151, UniProt: Q8WTS6 |
| Catalog # | ATGA0524 |
| Price | $190, $320 |
| Order / More Info | SETD7, Human Antibody from NKMAX Co. Ltd. |
| Product Specific References | Giannios I, et al. Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression. (Stem Cells. 2019){https://pubmed.ncbi.nlm.nih.gov/30681750/};;Si W, et al. SET7/9 promotes multiple malignant processes in breast cancer development via RUNX2 activation and is negatively regulated by TRIM21. (Cell Death Dis. 2020){https://pubmed.ncbi.nlm.nih.gov/32102992/};;Xie H, et al. METTL3/YTHDF2 m6 A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer. (J Cell Mol Med. 2020){https://pubmed.ncbi.nlm.nih.gov/32126149/};;Cao L, et al. Downregulation of SETD7 promotes migration and invasion of lung cancer cells via JAK2/STAT3 pathway. (Int J Mol Med. 2020){https://pubmed.ncbi.nlm.nih.gov/32323737/};;Jetton TL, et al. SetD7 (Set7/9) is a novel target of PPARγ that promotes the adaptive pancreatic β-cell glycemic response. (J Biol Chem. 2021){https://pubmed.ncbi.nlm.nih.gov/34592314/};;Li X, et al. Associating Preoperative MRI Features and Gene Expression Signatures of Early-stage Hepatocellular Carcinoma Patients using Machine Learning. (J Clin Transl Hepatol. 2022){https://pubmed.ncbi.nlm.nih.gov/35233374/};;Li J, et al. ZKSCAN5 Activates VEGFC Expression by Recruiting SETD7 to Promote the Lymphangiogenesis, Tumour Growth, and Metastasis of Breast Cancer. (Front Oncol. 2022){https://pubmed.ncbi.nlm.nih.gov/35600335/} |
NKMAX Co. Ltd.
NKMAX Co. Ltd.
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