RASSF1A, Human Antibody from NKMAX Co. Ltd.
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| Antigenic Specificity | RASSF1A, Human |
| Clone | AT3F3 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 kappa |
| Format | Protein A purified |
| Size | 50ul, 100ul |
| Concentration | 1mg/ml (determined by BCA assay) |
| Applications | ELISA, WB, ICC/IF |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The tumor suppressor gene RASSF1A (3p21.3), human Ras association domain family 1A, is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, small intestine, colon, and peripheral blood leukocytes. RASSF1A expression is inhibited by hypermethylation of the CpG island including the promoter and early transcribed regions of the human RASSF1A gene. Hypermethylated RASSF1A promoter is observed in primary tumors. Furthermore, RASSF1A is related with cell cycle regulation, apoptosis and microtubule stability. |
| Immunogen | Recombinant human RASSF1A (1-340aa) purified from E. coli. |
| Other Names | RASSF1(Ras association (RalGDS/AF-6) domain family 1),123F2, RDA32, NORE2A, RASSF1A, REH3P21, Ras association (RalGDS/AF-6) domain family member 1 |
| Gene, Accession # | NCBI: NP_009113, UniProt: Q9NS23 |
| Catalog # | ATGA0528 |
| Price | $190, $320 |
| Order / More Info | RASSF1A, Human Antibody from NKMAX Co. Ltd. |
| Product Specific References | Li W, et al. Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation. (Cell Death Differ. 2019){https://pubmed.ncbi.nlm.nih.gov/30315205/};;Guo M, et al. RASSF1-AS1, an antisense lncRNA of RASSF1A, inhibits the translation of RASSF1A to exacerbate cardiac fibrosis in mice. (Cell Biol Int. 2019){https://pubmed.ncbi.nlm.nih.gov/30571844/};;Dabral S, et al. A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension. (Nat Commun. 2019){https://pubmed.ncbi.nlm.nih.gov/31086178/};;Francisco J, et al. The tumor suppressor RASSF1A modulates inflammation and injury in the reperfused murine myocardium. (J Biol Chem. 2019){https://pubmed.ncbi.nlm.nih.gov/31311858/};;Chen J, et al. 5-Aza-CdR Regulates RASSF1A By Inhibiting DNMT1 To Affect Colon Cancer Cell Proliferation, Migration And Apoptosis. Cancer Manag Res. 2019{https://pubmed.ncbi.nlm.nih.gov/31807076/};;Slemmons KK, et al. Targeting Hippo-Dependent and Hippo-Independent YAP1 Signaling for the Treatment of Childhood Rhabdomyosarcoma. (Cancer Res. 2020){https://pubmed.ncbi.nlm.nih.gov/32354737/};;Dhanaraman T, et al. RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway. Sci Signal. 2020{https://pubmed.ncbi.nlm.nih.gov/33051258/};;Jeon HJ, Oh JS. RASSF1A Regulates Spindle Organization by Modulating Tubulin Acetylation via SIRT2 and HDAC6 in Mouse Oocytes. (Front Cell Dev Biol. 2020){https://pubmed.ncbi.nlm.nih.gov/33195286/};;Jia J, et al. RAS-association domain family 1A regulates the abnormal cell proliferation in psoriasis via inhibition of Yes-associated protein. (J Cell Mol Med. 2021){https://pubmed.ncbi.nlm.nih.gov/33960627/};;Roβwag S, et al. RASSF1A-Mediated Suppression of Estrogen Receptor Alpha (ERα)-Driven Breast Cancer Cell Growth Depends on the Hippo-Kinases LATS1 and 2. (Cells. 2021){https://pubmed.ncbi.nlm.nih.gov/34831091/} |
NKMAX Co. Ltd.
NKMAX Co. Ltd.
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