XBP-1 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | XBP-1 |
| Clone | 3H1G4 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1 |
| Format | Protein A purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | ELISA, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-XBP-1 Monoclonal Antibody was Protein A purified. Cross reactivity with XBP-1 [3H1G4] from other sources has not been determined. X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94. |
| Immunogen | Anti-XBP-1 antibody was produced in mice by repeated immunizations with recombinant protein corresponding to 158 amino acids near the N-terminus of human XBP-1. |
| Other Names | XBP-1 Antibody [3H1G4] , XBP2, TREB5, XBP-1 |
| Gene, Accession # | XBP1, Gene ID: 7494, NCBI: NP_001073007.1, UniProt: P17861 |
| Catalog # | 200-301-FZ8 |
| Price | $485 |
| Order / More Info | XBP-1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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