LAMP1 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | LAMP1 |
| Clone | Ly1C6 |
| Host Species | Mouse |
| Reactive Species | rat, hamster |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | Immunohistochemistry, Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-LAMP1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with LAMP1 from Hamster and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with LAMP1 from other sources has not been determined. Lysosome associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37% sequence homology. They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane. Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). If there is a disturbance in this spacing, lysosome localization of LAMP1 is abolished and the mutant protein then cycles between the membrane and the endosome. This stimulation has also been shown to have an associated release of histamine, leukotriene C and prostaglandin D, which shows that LAMP-1 and LAMP-2 are activation markers for normal mast cells. They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation. Ideal for investigators involved in cytokines, growth factors and cancer, as well as, Chaperones and Organelle Markers research. |
| Immunogen | LAMP1 Antibody was produced in mice by repeated immunizations raised against rat liver lysosomal membrane preparations. |
| Other Names | CD107, CD107a, LAMPA, LGP120, IgpA, Lysosome-associated membrane glycoprotein 1, CD107 antigen-like family member A, 120 kDa lysosomal membrane glycoprotein, Lamp-1 |
| Gene, Accession # | Lamp1, Gene ID: 25328, NCBI: NP_036989.1, UniProt: P14562 |
| Catalog # | 200-301-G09 |
| Price | $485 |
| Order / More Info | LAMP1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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