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Antigenic Specificity | HDAC9 (internal) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1.1 mg/mL |
Applications | ELISA, Immunohistochemistry, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-HDAC9 was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross-reactivity with human based on 100% sequence homology. Cross-reactivity with HDAC9 from other sources has not been determined. HDAC9 is located in the nucleus, expressed most highly in brain, heart, muscle, and testis. It is responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4). The result of deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDAC9 represses MEF2-dependent transcription by recruiting HDAC1 and 3. It appears to inhibit skeletal myogenesis and be a factor in heart development. By repressing JUN transcription via HDAC1 and inhibiting JUN phosphorylation by MAPK10, HDAC9 protects neurons from apoptosis. Anti-HDAC9 therefore is ideal for investigators interested in Cardiovascular or Epigenetics and Nuclear Signaling research. |
Immunogen | Anti-HDAC9 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the internal region of human HDAC9 protein. |
Other Names | rabbit anti-HDAC-9 antibody, HDAC9, HDAC 9, HD-9, HD 9, Histone deacetylase 9, Histone deacetylase-9, HD9, Histone deacetylase 7B, HD7, HD7b, Histone deacetylase-related protein, MEF2-interacting transcription repressor MITR, HDAC7, HDAC7B, HDRP, MITR |
Gene, Accession # | HDAC9 UniProt: Q9UKV0 |
Catalog # | 600-401-J74 |
Price | $475 |
Order / More Info | HDAC9 (internal) Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |