APOLIPOPROTEIN J Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | APOLIPOPROTEIN J |
| Clone | polyclonal |
| Host Species | Goat |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 500 µg |
| Concentration | 1.0 mg/mL |
| Applications | ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This product has been prepared by immunoaffinity chromatography using immobilized antigens followed by extensive cross-adsorption against other apoLipoproteins and human serum proteins to remove any unwanted specificities. Typically less than 1% cross reactivity against other types of apoLipoprotein was detected by ELISA against purified standards. This antibody reacts with human apoLipoprotein J and has negligible cross-reactivity with Type A-I, A-II, B, C-I, C-II, C-III and E apoLipoproteins. Specific cross reaction of anti-apoLipoprotein antibodies with antigens from other species has not been determined. Non-specific cross reaction of anti-apoLipoprotein antibodies with other human serum proteins is negligible. Apolipoprotein J Antibody functions as a secreted chaperone that prevents aggregation of nonnative proteins. It prevents stress-induced aggregation of blood plasma proteins and inhibits the formations of amyloid fibrils. Apolipoprotein J does not require ATP or refold proteins by itself. It maintains partially unfolded proteins in a state for subsequent refolding by other chaperones. It is shown to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Binding to cell surface receptors it triggers internalization of chaperone-client complex and subsequent lysosomal or proteasomal degradation. It modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis while mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Anti-Apolipoprotein J Antibody is useful for researchers interested in the immune system, Ubiquitin pathways, and cardiovascular research. |
| Immunogen | apoLipoprotein Type J was isolated from human plasma by density gradient centrifugation followed by HPLC purification. |
| Other Names | goat anti-Apolipoprotein J antibody, Clusterin, Complement-associated protein SP-40, Complement cytolysis inhibitor, CLI, NA1/NA2, Apo-J, Testosterone-repressed prostate message 2, TRPM-2, Ku70-binding protein 1, Aging-associated gene 4 protein, Clusterin beta chain, Clusterin alpha chain, Complement cytolysis inhibitor a chain, Complement cytolysis inhibitor b chain, ApoJ alpha, ApoJ beta, CLU, CLI, KUB1, AAG4 |
| Gene, Accession # | CLU, Gene ID: 1191, NCBI: NP_001822.3, UniProt: P10909 |
| Catalog # | 600-101-198 |
| Price | $549 |
| Order / More Info | APOLIPOPROTEIN J Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | PubMed: 19717566 // 34698771 |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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