Che-1 Phospho S477 (AATF) Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Che-1 Phospho S477 (AATF) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunoaffinity purified, no preservative |
| Size | 100 µL |
| Concentration | n/a |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Phospho- Ser477 Che-1 (AATF) Antibody is directed against AATF protein phosphorylated at S477. The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. This antibody is specific for phosphorylated AATF. Minimal reactivity occurs against non-phosphorylated AATF. Reactivity against AATF occurs from human sources. However, reactivity is also expected against bovine, canine, mouse, non-human primate, rat, sheep, and Xenopus based on 100% sequence homology. Che-1, also known as AATF (apoptosis-antagonizing transcription factor), is a RNA polymerase II-binding protein involved in regulating the transcription factor E2F and promoting cell cycle progression. It has been suggested that Che-1 may act as a neuroprotective factor against Abeta-induced apoptosis by suppressing the production of reactive oxidative species. The checkpoint kinase Chk2 has been shown to phosphorylate Che-1 at Ser477 contributing to the maintenance of the G2/M checkpoint induced by DNA damage. Che-1 pS477 Antibody is ideal for researchers interested in cell cycle research. |
| Immunogen | Anti-Phospho- Ser477 Che-1 (AATF) Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser477 of human Che-1 conjugated to KLH. |
| Other Names | Apoptosis-antagonizing transcription factor, Rb-binding protein Che-1, Che-1 |
| Gene, Accession # | AATF, Gene ID: 26574, NCBI: NP_036270.1, UniProt: Q9NY61 |
| Catalog # | 600-401-W99 |
| Price | $475 |
| Order / More Info | Che-1 Phospho S477 (AATF) Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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