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Antigenic Specificity | SNCA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-SNCA antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. SNCA antibody is human, mouse and rat reactive. At least three isoforms of SNCA are known to exist. Alpha-Synuclein (SNCA) is a hallmark of Alzheimer's disease (1,2). It is a cytoplasmic protein that is predominantly expressed in the central nervous system (2). SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to the decreased caspase-3 activation. SNCA may be involved in the regulation of dopamine release and transport and induces fibrillization of microtubule-associated protein tau (3). Defects in SNCA are associated with familial Parkinson's disease (4,5). |
Immunogen | Anti-SNCA antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid peptide near the C-terminus of human SNCA. |
Other Names | SNCA Antibody, PD1, NACP, PARK1, PARK4, Alpha-synuclein, Non-A beta component of AD amyloid |
Gene, Accession # | SNCA, Gene ID: 6622, NCBI: NP_000336.1, UniProt: P37840 |
Catalog # | 600-401-ER8 |
Price | $475 |
Order / More Info | SNCA Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |