Potassium Chloride Cotransporter (KCC2) phospho S940 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Potassium Chloride Cotransporter (KCC2) phospho S940 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | rat |
| Isotype | n/a |
| Format | immunoaffinity purified, no preservative |
| Size | 100 µL |
| Concentration | Sufficient for 10 mini blots (total final volume 100 ml at 1:1000 dilution) |
| Applications | Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Potassium Chloride Cotransporter (KCC2) pS940 antibody is directed against phosphorylated rat KCC2 protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling of the KCC2 protein band is blocked by the phospho-peptide used as antigen but not by the corresponding dephosphopeptide. Reactivity is expected from the following species based on 100% sequence homology: bovine, canine, human, mouse and non-human primate. Potassium Chloride Cotransporter pS940 Antibody detects Potassium Chloride Cotransporter pS940 protein. KCC2 is widely thought to be expressed exclusively in neurons where it is responsible for maintaining low intracellular chloride concentration to drive hyperpolarizing post-synaptic responses to the inhibitory neurotransmitters GABA and glycine. Serine 940 on KCC2 has been shown to be phosphorylated by PKC and has further been demonstrated to be the major site for PKC-dependent phosphorylation for full length KCC2 molecules when expressed in HEK-293 cells as phosphorylation of Ser940 increased the cell surface stability of KCC2 in this system by decreasing it's rate of internalization from the plasma membrane. Anti-Potassium Chloride Cotransporter (KCC2) pS940 Antibody is ideal for investigators involved in Neuroscience and Cell Signaling research. |
| Immunogen | Anti-Potassium Chloride Cotransporter (KCC2) pS940 Antibody was produced by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser940. |
| Other Names | Solute carrier family 12 member 5, Electroneutral potassium-chloride cotransporter 2, Furosemide-sensitive K-Cl cotransporter, K-Cl cotransporter 2, rKCC2, Neuronal K-Cl cotransporter, Kcc2 |
| Gene, Accession # | Slc12a5, Gene ID: 171373, UniProt: Q63633 |
| Catalog # | 612-401-E15 |
| Price | $475 |
| Order / More Info | Potassium Chloride Cotransporter (KCC2) phospho S940 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | PubMed: 29899451 // 30129982 // 30156863 // 31557760 // 31969605 |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
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