Edit |   |
---|---|
Antigenic Specificity | UEV1A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | ion exchange purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-UEV1A Antibody is purified by ion exchange chromatography. Anti-UEV1A may also recognize other isoforms of UEV1A. Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity. There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway. Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors. UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family. The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation. |
Immunogen | Anti-UEV1A antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to 15 amino acids near the C-terminus of human UEV1A. |
Other Names | UEV1A Antibody, CIR1, UEV1, CROC1, UBE2V, UEV-1, UEV1A, CROC-1, P/OKcl.19, Ubiquitin-conjugating enzyme E2 variant 1 |
Gene, Accession # | UBE2V1, Gene ID: 387522, NCBI: NP_001027459.1, UniProt: Q13404 |
Catalog # | 600-401-FU0 |
Price | $475 |
Order / More Info | UEV1A Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |