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Antigenic Specificity | Dynamin phospho S774 |
Clone | polyclonal |
Host Species | Sheep |
Reactive Species | rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µL |
Concentration | n/a |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Dynamin pS774 antibody is directed against Dynamin. Anti-Dynamin pS774 antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-sheep Serum. This antibody is specific for phosphorylated Dynamin pS774. Minimal reactivity occurs against non-phosphorylated Dynamin pS774. Reactivity is completely blocked by treatment with lambda-phosphatase. Reactivity against Dynamin pS774 occurs from rat sources. However, reactivity is also expected against bovine, canine, chicken, human, mouse and NHP. Dynamin Antibody detects Dynamin which is a member of a group of nerve terminal proteins called dephosphins that regulate synaptic vesicle endocytosis. Cyclin dependent protein kinase 5 phosphorylates dynamin at Ser774 and Ser778 that are the phosphorylation sites on dynamin phosphorylated in vivo. Phosphorylation of Ser774 by GSK3 has recently been shown to control activity-dependent bulk endocytosis of synaptic vesicles. Anti-Dynamin pS774 Antibody is ideal for investigators involved in Cell Signaling, Cell Motility, Neuroscience and Cancer Research. |
Immunogen | Anti-Dynamin pS774 Antibody was produced in sheep by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser774 conjugated to KLH. |
Other Names | sheep anti-Dynamin pS774 Antibody, Dynamin-1, B-dynamin, D100, Dnm, Dnm1 |
Gene, Accession # | Dnm1, Gene ID: 140694, NCBI: AAA16746.1, UniProt: P21575 |
Catalog # | 612-601-D32 |
Price | $475 |
Order / More Info | Dynamin phospho S774 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |