PAK 1 Phospho T84 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | PAK 1 Phospho T84 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified, no preservative |
| Size | 100 µL |
| Concentration | n/a |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Phospho-Thr84 PAK1 Antibody is directed against PAK1 protein phosphorylated at T84. The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. This antibody is specific for phosphorylated PAK1. Minimal reactivity occurs against non-phosphorylated PAK1. Reactivity against PAK1 occurs from human sources. However, reactivity is also expected against bovine, canine, chicken, non-human primates, sheep, and zebra fish based on 100% sequence homology. PAKs, p21 activated kinases, are a family of serine/threonine protein kinases comprised of six isoforms, PAK1-6, and they play important roles in cytoskeleton dynamics, cell survival and proliferation. Each of these isoforms contains a C-terminal catalytic domain and an N-terminal regulatory domain with a small G protein binding motif. OSR1, oxidative stress response 1, is activated only by osmotic stresses, like sorbital or NaCl. It has been predicted that OSR1 phosphorylates PAK1 in the regulatory domain at thr84 and inhibits activation of JNK and MAPK pathway. It has also been suggested that OSR1 may have a regulating function with actin cytoskeleton because it can phosphorylate PAK1 at thr84 and bind to gelsolin. PAK1 pT84 Antibody is ideal for researchers interested in cell cycle research. |
| Immunogen | Anti-Phospho-Thr84 PAK1 Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding the phospho-Thr84 of human PAK1 conjugated to KLH. |
| Other Names | Serine/Threonine-protein kinase PAK 1, Alpha-PAK, p21-activated kinase 1, p65-PAK |
| Gene, Accession # | PAK1, Gene ID: 5058, NCBI: NP_001122092.1, UniProt: Q13153 |
| Catalog # | 600-401-X21 |
| Price | $475 |
| Order / More Info | PAK 1 Phospho T84 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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