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Antigenic Specificity | ZIPK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-ZIPK Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with ZIPK from other sources has not been determined. Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase. ZIP kinase contains an N-terminal kinase domain and a C-terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREB family. ZIP kinase has high sequence homology to DAP kinase (death-associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities. The messenger RNA was ubiquitously expressed in various tissues. |
Immunogen | Anti-ZIP kinase antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to amino acids near the internal region of human ZIP kinase. |
Other Names | ZIPK Antibody, ZIP, ZIPK, Death-associated protein kinase 3, DAP-like kinase, DAP kinase 3, DAP-like kinase, Dlk, MYPT1 kinase, Zipper-interacting protein kinase, ZIP-kinase, DAPK3 |
Gene, Accession # | DAPK3, Gene ID: 1613, NCBI: NP_001339.1, UniProt: O43293 |
Catalog # | 600-401-GF5 |
Price | $475 |
Order / More Info | ZIPK Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |