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Antigenic Specificity | BAP31 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-BAP31 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with BAP31 from other sources has not been determined. Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family. These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18. It may also play a role in the initiation of ER stress-induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria. Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopicially, is also a potent inducer cell death. |
Immunogen | Anti-BAP31 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide from near the C-terminus of human BAP31. |
Other Names | BAP31 Antibody, CDM, DDCH, BAP31, 6C6-AG, DXS1357E, B-cell receptor-associated protein 31, 6C6-AG tumor-associated antigen, BCR-associated protein 31 |
Gene, Accession # | BCAP31, Gene ID: 10134, NCBI: NP_005736, UniProt: P51572 |
Catalog # | 600-401-Z32 |
Price | $475 |
Order / More Info | BAP31 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |