Noxa Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Noxa |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | Immunohistochemistry, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Noxa Antibody is immunoaffinity chromatography purified IgG. A BLAST analysis was used to suggest cross-reactivity with Noxa with Human, Mouse and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with Noxa from other sources has not been determined. Noxa antibody detects mouse Noxa. Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development. Anti-Noxa antibodies are ideal for investigators involved in Apoptosis and Cancer research. |
| Immunogen | Noxa Antibody was produced from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to amino acids at the n-terminus of mouse Noxa. |
| Other Names | Noxa, PMA-induced protein 1, PMAIP1, APR |
| Gene, Accession # | Pmaip1, Gene ID: 58801, UniProt: Q9JM54 |
| Catalog # | 600-401-H06 |
| Price | $475 |
| Order / More Info | Noxa Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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