BCL2 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | BCL2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat, bovine |
| Isotype | n/a |
| Format | Protein A purified |
| Size | 200 µg |
| Concentration | 2.0 mg/mL |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This purified IgG antibody was prepared from monospecific rabbit antiserum by Protein A chromatography. The antibody is directed against human Bcl-2 and is useful in determining its presence in various assays. Bcl-2 is a human proto-oncogene located chromosome 18. Its product is an integral membrane protein (also called Bcl-2) located in the membranes of the endoplasmic reticulum (ER), nuclear envelope, and in the outer membranes of the mitochondria. The gene was discovered as the translocated locus in a B-cell leukemia (hence the name). This translocation is also found in some B-cell lymphomas. In the cancerous B cells, the portion of chromosome 18 containing the BCL-2 locus has undergone a reciprocal translocation with the portion of chromosome 14 containing the antibody heavy chain locus. This t(14;18) translocation places the BCL-2 gene close to the heavy chain gene enhancer. This enhancer is very active in B cells and therefore results in high levels of Bcl-2 expression in these cells. High levels of the Bcl-2 protein protect the cells from early death by apoptosis. The Bcl-2 protein suppresses apoptosis by preventing the activation of the caspases that carry out the process. It is conceived that introduction of the Bcl-2 gene into the cells of injured tissue will reduce cell death and improve the clinical outcome of the injury. Anti-BCL-2 Antibody is useful for researchers interested in lymphoma, breast cancer, and apoptosis research. |
| Immunogen | This purified IgG antibody was prepared from rabbit serum by repeated immunizations with a synthetic peptide corresponding to amino acids 62-76 (RDPVARTSPLQTPAA) of human Bcl-2. |
| Other Names | rabbit anti-Bcl-2 antibody, Apoptosis regulator Bcl 2 antibody, Apoptosis regulator Bcl2 antibody, AW986256 antibody, B cell CLL/lymphoma 2 antibody, B cell leukemia/lymphoma 2 antibody, B cell lymphoma 2 antibody, Bcl 2 antibody |
| Gene, Accession # | BCL2, Gene ID: 596, NCBI: NP_000624.2, UniProt: P10415 |
| Catalog # | 200-401-222 |
| Price | $475 |
| Order / More Info | BCL2 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | PubMed: 29317678 |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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