KINDLIN3 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | KINDLIN3 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-KINDLIN3 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with KINDLIN3 from other sources has not been determined. The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes. |
| Immunogen | Anti-KINDLIN3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid synthetic peptide near the C-terminus of the human KINDLIN3. |
| Other Names | KINDLIN3 Antibody, URP2, KIND3, MIG-2, MIG2B, URP2SF, UNC112C, URP2, Fermitin family homolog 3, Kindlin-3 |
| Gene, Accession # | FERMT3, Gene ID: 83706, NCBI: NP_848537, UniProt: Q86UX7 |
| Catalog # | 600-401-CE5 |
| Price | $475 |
| Order / More Info | KINDLIN3 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
Profile of ROCKLAND IMMUNOCHEMICALS INC.