SHANK3 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | SHANK3 |
| Clone | S69 |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG2b |
| Format | Protein G purified |
| Size | 100 µg |
| Concentration | 1.0 mg/mL |
| Applications | Immunohistochemistry, IF Microscopy, Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-SHANK3 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with SHANK3 from human, mouse, and rat based on 100% homology with the immunizing sequence. No cross-reactivity against Shank1 or Shank2. Cross-reactivity with SHANK3 from other sources has not been determined. Scaffolds research. Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are also crucial in receptor tyrosine kinase signaling; specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation.Shank3 is also one of the latest genes to be associated with autism. A mutation of a single copy of Shank3 on chromosome 22q13 can result in language and/or social communication disorders. |
| Immunogen | SHANK3 Antibody was produced in mice by repeated immunizations raised against a synthetic peptide corresponding to an internal region of rat Shank3. |
| Other Names | Shank3, Prosap2, SH3 and multiple ankyrin repeat domains protein 3, Proline-rich synapse-associated protein 2 |
| Gene, Accession # | Shank3, Gene ID: 59312, NCBI: NP_067708.1, UniProt: Q9JLU4 |
| Catalog # | 200-301-G45 |
| Price | $485 |
| Order / More Info | SHANK3 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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