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Antigenic Specificity | NMDA R1, Splice Variant C2' |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 25 µg |
Concentration | n/a |
Applications | Immunohistochemistry, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-NMDA R1, Splice Variant C2' antibody is directed against NMDA R1 protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. This antibody does not recognize the NR1 subunits of the NMDA receptor that do not contain the C2' insert. Reactivity is expected from the following species based on 100% sequence homology: bovine, human. NMDA R1, Splice Variant C2' Antibody detects NMDA R1 protein. The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. Increased membrane surface expression of the NMDAR, NR1-Subunit has been associated with synaptic plasticity. There are a number of different splice variants of the NR1-Subunit. Differential splicing of three exons in the NR1-Subunit generates up to eight NR1-Subunit splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR. Anti-NMDA R1, Splice Variant C2' Antibody is ideal for investigators involved in Neuroscience and Signal Transduction research. |
Immunogen | Anti-NMDA R1, Splice Variant C2' Antibody was produced by repeated immunizations with synthetic peptide corresponding to amino acid residues specific to the NR1 subunit, C2' splice variant insert. |
Other Names | Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1, NMD-R1, Grin1 |
Gene, Accession # | Grin1, Gene ID: 24408, NCBI: NP_058706.1, UniProt: P35439 |
Catalog # | 600-401-D87 |
Price | $475 |
Order / More Info | NMDA R1, Splice Variant C2' Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |